The trajectory of base editing has been remarkable, progressing from the laboratory to patient care, treating debilitating or ...

A study published in the journal Science reveals how jumping fragments of human DNA, a type of genetic parasite, destabilize ...

BACKGROUND: Aortic valve calcification increases leaflet stiffness and contributes to the development of calcific aortic valve disease. The molecular and cellular mechanisms underlying calcification ...

A gel held together entirely by interlocking DNA rings exhibits mechanical properties unlike any conventional gel, driven ...

DNA topoisomerase-IA is an essential enzyme that relaxes supercoiled DNA by introducing transient single-strand breaks through a covalent phosphorylated tyrosine (PTR) intermediate. This cleavage ...

Nucleotide synthesis—the production of the basic components of DNA and RNA—is essential for cell growth and division. In most animal cells, this process depends closely on properly functioning ...

Researchers have uncovered how a key DNA repair enzyme is recruited and activated inside cells, answering long-standing questions about how cells protect and repair their DNA and providing the ...

Enzymes help with specific functions that are vital to the operation and overall health of the human body. They help speed up chemical reactions and are essential for respiration, digestion, muscle ...

Aging, neurological diseases and our bodies' stress response are all linked to the tiny power plants inside each cell known as mitochondria. To function properly, mitochondria must first read ...

The mutagenic potential of hydroxychloroquine has not been evaluated. However, chloroquine has been shown to be a catalytic inhibitor of DNA repair enzymes (topoisomerase II) and to produce weak ...