"There is no credible evidence that puberty blockers... address anxiety, depression, suicidal ideation," Leor Sapir tells me. In a recent interview, Sapir, a senior fellow at the Manhattan Institute and co-author of the 2025 HHS review of pediatric gender medicine, detailed a systemic lack of rigor and transparency within the field. According to Sapir, the research landscape is frequently compromised by professional and ideological interests: "The people who do studies in this area are typically

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